Targeting Calcineurin for Improving Muscle Regeneration in Skeletal Muscle Disease

Grant number: 350439

Abstract

Muscular dystrophy is a term that covers a diverse group of inherited disorders characterised by progressive muscle weakness and wasting. Duchenne muscular dystrophy (DMD) is the most severe form, caused by a lack of a protein called dystrophin, which renders muscles fragile, susceptible to damage, and with a compromised ability to regenerate or repair after injury. The disease progresses to all muscles and DMD patients are dependent on a wheelchair before their early teens and die in their twenties. There is a profound need for treatments that can ameliorate the dystrophic condition and improve patient quality of life. Restoring or increasing a muscle's capacity to regenerate would help imp..

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Related publications (7)

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Background: Some of the most serious consequences of normal ageing relate to its effects on skeletal muscle, particularly signific..

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The β-adrenergic signaling pathway represents a novel therapeutic target for skeletal muscle wasting and weakness due to its role ..

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Anabolic agents for improving muscle regeneration and function after injury

GS Lynch, JD Schertzer, JG Ryall

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1. In the present review, we describe how muscles can be injured by external factors, internal factors or during the performance o..

Notexin causes greater myotoxic damage and slower functional repair in mouse skeletal muscles than bupivacaine

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Although the myotoxins bupivacaine and notexin are employed for studying processes that regulate muscle regeneration after injury,..

Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice

N Stupka, DR Plant, JD Schertzer, TM Emerson, R Bassel-Duby, EN Olson, GS Lynch

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Utrophin expression is regulated by calcineurin and up-regulating utrophin can decrease the susceptibility of dystrophic skeletal ..

Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice

N Stupka, BJ Michell, BE Kemp, GS Lynch

2006-05-01

Calcineurin activity is essential for successful skeletal muscle regeneration in young mdx mice and in wild type mice following my..

University of Melbourne Researchers

Gordon Lynch